Featured Publications
PREPRINT | 2024
Visual foundation models for fast, label-free detection of diffuse glioma infiltrationAkhil Kondepudi, Melike Pekmezci, Xinhai Hou, Katie Scotford, Cheng Jiang, Akshay Rao, Edward Harake, Asadur Chowdury, Wajd Al-Holou, Lin Wang, Aditya Pandey, Pedro Lowenstein, Maria Castro, Lisa Koerner, Thomas Roetzer-Pejrimovsky, Georg Widhalm, Sandra Camelo-Piragua, Misha Movahed-Ezazi, Daniel Orringer, Honglak Lee, Christian Freudiger, Mitchel Berger, Shawn Hervey-Jumper, and Todd Hollon
CVPR | 2023
Hierarchical Discriminative Learning Improves Visual Representations of Biomedical MicroscopyCheng Jiang*, Xinhai Hou*, Akhil Kondepudi, Asadur Chowdury, Christian W. Freudiger, Daniel A. Orringer, Honglak Lee, and Todd C. Hollon
NATURE MEDICINE | 2023
AI-based molecular classification of diffuse gliomas using rapid, label-free optical imagingTodd Hollon, Cheng Jiang, Asadur Chowdury, Mustafa Nasir-Moin, Akhil Kondepudi, Alexander Aabedi, Arjun Adapa, Wajd Al-Holou, Jason Heth, Oren Sagher, Pedro Lowenstein, Maria Castro, Lisa Irina Wadiura, Georg Widhalm, Volker Neuschmelting, David Reinecke, Niklas von Spreckelsen, Mitchel Berger, Shawn Hervey-Jumper, John Golfinos, Matija Snuderl, Sandra Camelo-Piragua, Christian Freudiger, Honglak Lee, and Daniel Orringer
NEURIPS DATASETS & BENCHMARKS | 2022
OpenSRH: optimizing brain tumor surgery using intraoperative stimulated Raman histologyCheng Jiang*, Asadur Chowdury*, Xinhai Hou*, Akhil Kondepudi, Christian W. Freudiger, Kyle Conway, Sandra Camelo-Piragua, Daniel A. Orringer, Honglak Lee, and Todd C. Hollon
NATURE MEDICINE | 2020
Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networksTodd C Hollon, Balaji Pandian, Arjun R Adapa, Esteban Urias, Akshay V Save, Siri Sahib S Khalsa, Daniel G Eichberg, Randy S D'Amico, Zia U Farooq, Spencer Lewis, Petros D Petridis, Tamara Marie, Ashish H Shah, Hugh J L Garton, Cormac O Maher, Jason A Heth, Erin L McKean, Stephen E Sullivan, Shawn L Hervey-Jumper, Parag G Patil, B Gregory Thompson, Oren Sagher, Guy M McKhann 2nd, Ricardo J Komotar, Michael E Ivan, Matija Snuderl, Marc L Otten, Timothy D Johnson, Michael B Sisti, Jeffrey N Bruce, Karin M Muraszko, Jay Trautman, Christian W Freudiger, Peter Canoll, Honglak Lee, Sandra Camelo-Piragua, Daniel A Orringer
NATURE BIOMEDICAL ENGINEERING | 2017
Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopyDaniel A Orringer, Balaji Pandian, Yashar S Niknafs, Todd C Hollon, Julianne Boyle, Spencer Lewis, Mia Garrard, Shawn L Hervey-Jumper, Hugh J L Garton, Cormac O Maher, Jason A Heth, Oren Sagher, D Andrew Wilkinson, Matija Snuderl, Sriram Venneti, Shakti H Ramkissoon, Kathryn A McFadden, Amanda Fisher-Hubbard, Andrew P Lieberman, Timothy D Johnson, X Sunney Xie, Jay K Trautman, Christian W Freudiger, Sandra Camelo-Piragua
Publications
PREPRINT | 2024
Visual foundation models for fast, label-free detection of diffuse glioma infiltrationAkhil Kondepudi, Melike Pekmezci, Xinhai Hou, Katie Scotford, Cheng Jiang, Akshay Rao, Edward Harake, Asadur Chowdury, Wajd Al-Holou, Lin Wang, Aditya Pandey, Pedro Lowenstein, Maria Castro, Lisa Koerner, Thomas Roetzer-Pejrimovsky, Georg Widhalm, Sandra Camelo-Piragua, Misha Movahed-Ezazi, Daniel Orringer, Honglak Lee, Christian Freudiger, Mitchel Berger, Shawn Hervey-Jumper, and Todd Hollon
NATURE BIOMEDICAL ENGINEERING | 2024
Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopyMustafa Nasir-Moin, Lisa Irina Wadiura, Vlad Sacalean, Devin Juros, Misha Movahed-Ezazi, Emily K. Lock, Andrew Smith, Matthew Lee, Hannah Weiss, Michael Müther, Daniel Alber, Sujay Ratna, Camila Fang, Eric Suero-Molina, Sönke Hellwig, Walter Stummer, Karl Rössler, Johannes A. Hainfellner, Georg Widhalm, Barbara Kiesel, David Reichert, Mario Mischkulnig, Rajan Jain, Jakob Straehle, Nicolas Neidert, Oliver Schnell, Jürgen Beck, Jay Trautman, Steve Pastore, Donato Pacione, Dimitris Placantonakis, Eric Karl Oermann, John G. Golfinos, Todd C. Hollon, Matija Snuderl, Christian W. Freudiger, Dieter Henrik Heiland, and Daniel A. Orringer
ARXIV | 2024
A self-supervised framework for learning whole slide representationsXinhai Hou *, Cheng Jiang*, Akhil Kondepudi, Yiwei Lyu, Asadur Zaman Chowdury, Honglak Lee, and Todd C. Hollon
Cheng Jiang, Alexander Gedeon, Yiwei Lyu, Eric Landgraf, Yufeng Zhang, Xinhai Hou, Akhil Kondepudi, Asadur Chowdury, Honglak Lee, and Todd C. Hollon
ARXIV | 2024
Step-Calibrated Diffusion for Biomedical Optical Image RestorationYiwei Lyu, Sung Jik Cha, Cheng Jiang, Asadur Chowdury, Xinhai Hou, Edward Harake, Akhil Kondepudi, Christian Freudiger, Honglak Lee, and Todd C. Hollon
JOURNAL OF NEUROSURGERY SPINE | 2024
Development and Validation of an Artificial Intelligence Model to Accurately Predict Spinopelvic ParametersEdward S. Harake, Joseph R. Linzey, Cheng Jiang, Rushikesh S. Joshi, Mark M. Zaki, Jaes C. Jones, Siri S. Khalsa, John H. Lee, Zachary Wilseck, Jacob R. Joseph, Todd C. Hollon, and Paul Park
Yoshie Umemura, Daniel Orringer, Larry Junck, Maria L Varela, Molly E J West, Syed M Faisal, Andrea Comba, Jason Heth, Oren Sagher, Denise Leung, Aaron Mammoser, Shawn Hervey-Jumper, Daniel Zamler, Viveka N Yadav, Patrick Dunn, Wajd Al-Holou, Todd Hollon, Michelle M Kim, Daniel R Wahl, Sandra Camelo-Piragua, Andrew P Lieberman, Sriram Venneti, Paul McKeever, Theodore Lawrence, Ryo Kurokawa, Karen Sagher, David Altshuler, Lili Zhao, Karin Muraszko, Maria G Castro, and Pedro R Lowenstein
Cheng Jiang*, Xinhai Hou*, Akhil Kondepudi, Asadur Chowdury, Christian W. Freudiger, Daniel A. Orringer, Honglak Lee, and Todd C. Hollon
Todd Hollon, Cheng Jiang, Asadur Chowdury, Mustafa Nasir-Moin, Akhil Kondepudi, Alexander Aabedi, Arjun Adapa, Wajd Al-Holou, Jason Heth, Oren Sagher, Pedro Lowenstein, Maria Castro, Lisa Irina Wadiura, Georg Widhalm, Volker Neuschmelting, David Reinecke, Niklas von Spreckelsen, Mitchel Berger, Shawn Hervey-Jumper, John Golfinos, Matija Snuderl, Sandra Camelo-Piragua, Christian Freudiger, Honglak Lee, and Daniel Orringer
Wajd N. Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel GW Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel R Wahl, Todd Hollon, Oren Sagher, Jason A Heth, Karin M. Muraszko, Theodore S. Lawrence, Ana C de Carvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla
NEURIPS DATASETS & BENCHMARKS | 2022
OpenSRH: optimizing brain tumor surgery using intraoperative stimulated Raman histologyCheng Jiang*, Asadur Chowdury*, Xinhai Hou*, Akhil Kondepudi, Christian W. Freudiger, Kyle Conway, Sandra Camelo-Piragua, Daniel A. Orringer, Honglak Lee, and Todd C. Hollon
Rachel Gologorsky, Edward Harake, Grace von Oiste, Mustafa Nasir-Moin, William Couldwell, Eric Oermann, and Todd Hollon
Alexander T M Cheung, Mustafa Nasir-Moin, Young Joon Fred Kwon, Jiahui Guan, Chris Liu, Lavender Jiang, Christian Raimondo, Silky Chotai, Lola Chambless, Hasan S Ahmad, Daksh Chauhan, Jang W Yoon, Todd Hollon, Vivek Buch, Douglas Kondziolka, Dinah Chen, Lama A Al-Aswad, Yindalon Aphinyanaphongs, and Eric Karl Oermann
Eric E. Babajanian, Todd C. Hollon, Tori A. Seasor, William Couldwell, and Richard K. Gurgel
Abhishek Bhattacharya, Daniel Alber, and Todd Hollon
Vance L.Fredrickson Todd C.Hollon Robert C.Rennert Marcus D.Mazur Andrew T.Dailey, and William T.Couldwell
Andrea Comba, Syed M. Faisal, Patrick J. Dunn, Anna E. Argento, Todd C. Hollon, Wajd N. Al-Holou, Maria Luisa Varela, Daniel B. Zamler, Gunnar L. Quass, Pierre F. Apostolides, Clifford Abel II, Christine E. Brown, Phillip E. Kish, Alon Kahana, Celina G. Kleer, Sebastien Motsch, Maria G. Castro and Pedro R. Lowenstein
Cheng Jiang, Abhishek Bhattacharya, Joseph Linzey, Rushikesh Joshi, Sung Jik Cha, Sudharsan Srinivasan, Daniel Alber, Akhil Kondepudi, Esteban Urias, Balaji Pandian, Wajd Al-Holou, Steve Sullivan, B. Gregory Thompson, Jason Heth, Chris Freudiger, Siri Khalsa, Donato Pacione, John G. Golfinos, Sandra Camelo-Piragua, Daniel A. Orringer, Honglak Lee, and Todd Hollon
Todd Hollon, Vance Fredrickson, William Couldwell
Vance L Fredrickson, Guilherme J Agnoletto, Todd C Hollon, Bornali Kundu, Vance R Mortimer, William T Couldwell
Vance L Fredrickson, Serge Makarenko, Todd C Hollon, Robert C Rennert, Ramesh Grandhi, William T Couldwell
Andrea Comba, Syed M Faisal, Maria Luisa Varela, Todd Hollon, Wajd N Al-Holou, Yoshie Umemura, Felipe J Nunez, Sebastien Motsch, Maria G Castro, and Pedro R Lowenstein
Davide Marco Croci, Vance L. Fredrickson, Todd C. Hollon, Andrew T. Dailey, and William T. Couldwell
JOURNAL OF NEURO-ONCOLOGY | 2021
Label-free brain tumor imaging using Raman-based methodsTodd Hollon and Daniel A. Orringer
Todd C Hollon, Balaji Pandian, Esteban Urias, Akshay V Save, Arjun R Adapa, Sudharsan Srinivasan, Neil K Jairath, Zia Farooq, Tamara Marie, Wajd N Al-Holou, Karen Eddy, Jason A Heth, Siri Sahib S Khalsa, Kyle Conway, Oren Sagher, Jeffrey N Bruce, Peter Canoll, Christian W Freudiger, Sandra Camelo-Piragua, Honglak Lee, Daniel A Orringer
METHODS IN MOLECULAR BIOLOGY | 2021
Clinical Translation of Stimulated Raman HistologyCordelia Orillac, Todd Hollon, Daniel A Orringer
Haley K Talbot-Stetsko, Kristen D Raue, Bryan L Aaron, Arjun R Adapa, David B Altshuler, Sudharsan Srinivasan, Aditya S Pandey, Cormac O Maher, Todd C Hollon, Siri Sahib S Khalsa
Guilherme J Agnoletto, Vance L Fredrickson, Todd C Hollon, William T Couldwell
Austin Gamblin, Vance L Fredrickson, Todd C Hollon, Karen L Salzman, William T Couldwell
JOURNAL OF NEUROSURGERY | 2020
Volumetric quantification of aneurysmal subarachnoid hemorrhage independently predicts hydrocephalus and seizuresBadih J. Daou, Siri Sahib S. Khalsa, Sharath Kumar Anand, Craig A. Williamson, Noah S. Cutler, Bryan L. Aaron, Sudharsan Srinivasan, Venkatakrishna Rajajee, Kyle Sheehan, and Aditya S. Pandey
JOURNAL OF NEUROSURGERY PEDIATRICS | 2020
Normal cerebral ventricular volume growth in childhoodNoah S Cutler , Sudharsan Srinivasan , Bryan L Aaron, Sharath Kumar Anand , Michael S Kang, David B Altshuler, Thomas C Schermerhorn, Todd C Hollon , Cormac O Maher , and Siri Sahib S Khalsa
Siri Sahib S Khalsa, Todd C Hollon, Arjun Adapa, Esteban Urias, Sudharsan Srinivasan, Neil Jairath, Julianne Szczepanski, Peter Ouillette, Sandra Camelo-Piragua, Daniel A Orringer
Todd C Hollon, Balaji Pandian, Arjun R Adapa, Esteban Urias, Akshay V Save, Siri Sahib S Khalsa, Daniel G Eichberg, Randy S D'Amico, Zia U Farooq, Spencer Lewis, Petros D Petridis, Tamara Marie, Ashish H Shah, Hugh J L Garton, Cormac O Maher, Jason A Heth, Erin L McKean, Stephen E Sullivan, Shawn L Hervey-Jumper, Parag G Patil, B Gregory Thompson, Oren Sagher, Guy M McKhann 2nd, Ricardo J Komotar, Michael E Ivan, Matija Snuderl, Marc L Otten, Timothy D Johnson, Michael B Sisti, Jeffrey N Bruce, Karin M Muraszko, Jay Trautman, Christian W Freudiger, Peter Canoll, Honglak Lee, Sandra Camelo-Piragua, Daniel A Orringer
MOLECULAR & CELLULAR ONCOLOGY | 2020
An automated tissue-to-diagnosis pipeline using intraoperative stimulated Raman histology and deep learningTodd C. Hollon and Daniel A. Orringer
Esteban Urias, Christopher Freudiger, Daniel Orringer, Honglak Lee, and Todd Hollon
Mark L Schultz, Maria V Fawaz, Ruth D Azaria, Todd C Hollon, Elaine A Liu, Thaddeus J Kunkel, Troy A Halseth, Kelsey L Krus, Ran Ming, Emily E Morin, Hayley S McLoughlin, David D Bushart, Henry L Paulson, Vikram G Shakkottai, Daniel A Orringer, Anna S Schwendeman, Andrew P Lieberman
NEUROSURGERY CLINICS OF NORTH AMERICA | 2019
Surgical Adjuncts to Increase the Extent of Resection: Intraoperative MRI, Fluorescence, and Raman HistologyTodd Hollon, Walter Stummer, Daniel Orringer, Eric Suero Molina
JOURNAL OF NEUROSURGERY | 2018
A machine learning approach to predict early outcomes after pituitary adenoma surgeryTodd C Hollon, Adish Parikh, Balaji Pandian, Jamaal Tarpeh, Daniel A Orringer, Ariel L Barkan, Erin L McKean, Stephen E Sullivan
Lynze R Franko, Todd Hollon, Joseph Linzey, Christopher Roark, Venkatakrishna Rajajee, Kyle Sheehan, Magnus Teig, Shawn Hervey-Jumper, Jason Heth, Daniel Orringer, Craig A Williamson
Todd C Hollon, Luis E Savastano, David Altshuler, Ariel L Barkan, Stephen E Sullivan
CLINICAL CANCER RESEARCH | 2018
Shedding Light on IDH1 Mutation in GliomasTodd C Hollon, Daniel A Orringer
JOURNAL OF NEUROSURGERY | 2017
Korsakoff syndrome from retrochiasmatic suprasellar lesions: rapid reversal after relief of cerebral compression in 4 casesLuis E Savastano, Todd C Hollon, Ariel L Barkan, Stephen E Sullivan
JOURNAL OF NEUROLOGICAL SURGERY | 2018
Surgical Treatment of Olfactory Neuroblastoma: Major Complication Rates, Progression Free and Overall SurvivalAileen Wertz, Todd Hollon, Lawrence J Marentette, Stephen E Sullivan, Jonathan B McHugh, Erin L McKean
JOURNAL OF CLINICAL NEUROSCIENCE | 2018
Primary diffuse leptomeningeal melanomatosis: Description and recommendationsYamaan S Saadeh, Todd C Hollon, Amanda Fisher-Hubbard, Luis E Savastano, Paul E McKeever, Daniel A Orringer
Todd C Hollon, Luis E Savastano, Davis P Argersinger, Douglas J Quint, B Gregory Thompson
Todd C Hollon, Spencer Lewis, Balaji Pandian, Yashar S Niknafs, Mia R Garrard, Hugh Garton, Cormac O Maher, Kathryn McFadden, Matija Snuderl, Andrew P Lieberman, Karin Muraszko, Sandra Camelo-Piragua, Daniel A Orringer
JOURNAL OF NEUROINTERVENTIONAL SURGERY | 2016
Spontaneous subarachnoid hemorrhage due to ruptured cavernous internal carotid artery aneurysm after medical prolactinoma treatmentSiri Sahib Khalsa, Todd C Hollon, Ravi Shastri, Jonathan D Trobe, Joseph J Gemmete, and Aditya S Pandey
JOURNAL OF NEUROSURGERY PEDIATRICS | 2017
Comparison of posterior fossa volumes and clinical outcomes after decompression of Chiari malformation Type ISiri Sahib S Khalsa, Alan Siu, Tiffani A DeFreitas, Justin M Cappuzzo, John S Myseros, Suresh N Magge, Chima O Oluigbo, and Robert F Keating
NATURE BIOMEDICAL ENGINEERING | 2017
Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopyDaniel A Orringer, Balaji Pandian, Yashar S Niknafs, Todd C Hollon, Julianne Boyle, Spencer Lewis, Mia Garrard, Shawn L Hervey-Jumper, Hugh J L Garton, Cormac O Maher, Jason A Heth, Oren Sagher, D Andrew Wilkinson, Matija Snuderl, Sriram Venneti, Shakti H Ramkissoon, Kathryn A McFadden, Amanda Fisher-Hubbard, Andrew P Lieberman, Timothy D Johnson, X Sunney Xie, Jay K Trautman, Christian W Freudiger, Sandra Camelo-Piragua
JOURNAL OF NEUROSURGERY PEDIATRICS | 2017
Morphometric and volumetric comparison of 102 children with symptomatic and asymptomatic Chiari malformation Type ISiri Sahib S Khalsa, Ndi Geh, Bryn A Martin, Philip A Allen, Jennifer Strahle, Francis Loth, Desale Habtzghi, Aintzane Urbizu Serrano, Daniel McQuaide, Hugh J L Garton, Karin M Muraszko, Cormac O Maher
JOURNAL OF NEUROSURGERY | 2016
Supratentorial hemispheric ependymomas: an analysis of 109 adults for survival and prognostic factorsTodd Hollon, Vincent Nguyen, Brandon W Smith, Spencer Lewis, Larry Junck, Daniel A Orringer
Zhe Guan, Thomas J Wilson, Jon A Jacobson, Todd C Hollon, Lynda J-S Yang
JOURNAL OF NEUROSURGERY | 2016
Improving the accuracy of brain tumor surgery via Raman-based technologyTodd Hollon, Spencer Lewis, Christian W Freudiger, X Sunney Xie, Daniel A Orringer
Todd Hollon, Sandra I Camelo-Piragua, Erin L McKean, Stephen E Sullivan, Hugh J L Garton
William F Chandler, Ariel L Barkan, Todd Hollon, Alla Sakharova, Jayson Sack, Barunashish Brahma, David E Schteingart
JOURNAL OF NEUROSURGERY | 2015
Ruptured pediatric cerebellopontine angle epidermoid cyst: a case report detailing radiographic evolution and clinical courseZhe Guan, Todd Hollon, J Nicole Bentley, Hugh J L Garton
SEMINARS IN RADIATION ONCOLOGY | 2015
Advances in the Surgical Management of Low-Grade GliomaTodd Hollon, Shawn L Hervey-Jumper, Oren Sagher, Daniel A Orringer
Todd Hollon, Paul E McKeever, Hugh J L Garton, Cormac O Maher
Todd C Hollon, Richard L Price, Chang-Hyuk Kwon, E Antonio Chiocca
Richard L Price, Jieun Song, Katherine Bingmer, Tae Hyong Kim, Ji-Yeun Yi, Michal O Nowicki, Xiaokui Mo, Todd Hollon, Eric Murnan, Christopher Alvarez-Breckenridge, Soledad Fernandez, Balveen Kaur, Andreana Rivera, Michael Oglesbee, Charles Cook, E Antonio Chiocca, Chang-Hyuk Kwon