Featured Publications

NATURE | 2024

Foundation models for fast, label-free detection of glioma infiltration

Akhil Kondepudi, Melike Pekmezci, Xinhai Hou, Katie Scotford, Cheng Jiang, Akshay Rao, Edward Harake, Asadur Chowdury, Wajd Al-Holou, Lin Wang, Aditya Pandey, Pedro Lowenstein, Maria Castro, Lisa Koerner, Thomas Roetzer-Pejrimovsky, Georg Widhalm, Sandra Camelo-Piragua, Misha Movahed-Ezazi, Daniel Orringer, Honglak Lee, Christian Freudiger, Mitchel Berger, Shawn Hervey-Jumper, and Todd Hollon

CVPR | 2023

Hierarchical Discriminative Learning Improves Visual Representations of Biomedical Microscopy

Cheng Jiang*, Xinhai Hou*, Akhil Kondepudi, Asadur Chowdury, Christian W. Freudiger, Daniel A. Orringer, Honglak Lee, and Todd C. Hollon

NATURE MEDICINE | 2023

AI-based molecular classification of diffuse gliomas using rapid, label-free optical imaging

Todd Hollon, Cheng Jiang, Asadur Chowdury, Mustafa Nasir-Moin, Akhil Kondepudi, Alexander Aabedi, Arjun Adapa, Wajd Al-Holou, Jason Heth, Oren Sagher, Pedro Lowenstein, Maria Castro, Lisa Irina Wadiura, Georg Widhalm, Volker Neuschmelting, David Reinecke, Niklas von Spreckelsen, Mitchel Berger, Shawn Hervey-Jumper, John Golfinos, Matija Snuderl, Sandra Camelo-Piragua, Christian Freudiger, Honglak Lee, and Daniel Orringer

NEURIPS DATASETS & BENCHMARKS | 2022

OpenSRH: optimizing brain tumor surgery using intraoperative stimulated Raman histology

Cheng Jiang*, Asadur Chowdury*, Xinhai Hou*, Akhil Kondepudi, Christian W. Freudiger, Kyle Conway, Sandra Camelo-Piragua, Daniel A. Orringer, Honglak Lee, and Todd C. Hollon

NATURE MEDICINE | 2020

Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks

Todd C Hollon, Balaji Pandian, Arjun R Adapa, Esteban Urias, Akshay V Save, Siri Sahib S Khalsa, Daniel G Eichberg, Randy S D'Amico, Zia U Farooq, Spencer Lewis, Petros D Petridis, Tamara Marie, Ashish H Shah, Hugh J L Garton, Cormac O Maher, Jason A Heth, Erin L McKean, Stephen E Sullivan, Shawn L Hervey-Jumper, Parag G Patil, B Gregory Thompson, Oren Sagher, Guy M McKhann 2nd, Ricardo J Komotar, Michael E Ivan, Matija Snuderl, Marc L Otten, Timothy D Johnson, Michael B Sisti, Jeffrey N Bruce, Karin M Muraszko, Jay Trautman, Christian W Freudiger, Peter Canoll, Honglak Lee, Sandra Camelo-Piragua, Daniel A Orringer

NATURE BIOMEDICAL ENGINEERING | 2017

Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy

Daniel A Orringer, Balaji Pandian, Yashar S Niknafs, Todd C Hollon, Julianne Boyle, Spencer Lewis, Mia Garrard, Shawn L Hervey-Jumper, Hugh J L Garton, Cormac O Maher, Jason A Heth, Oren Sagher, D Andrew Wilkinson, Matija Snuderl, Sriram Venneti, Shakti H Ramkissoon, Kathryn A McFadden, Amanda Fisher-Hubbard, Andrew P Lieberman, Timothy D Johnson, X Sunney Xie, Jay K Trautman, Christian W Freudiger, Sandra Camelo-Piragua

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Publications

NATURE | 2024

Foundation models for fast, label-free detection of glioma infiltration

Akhil Kondepudi, Melike Pekmezci, Xinhai Hou, Katie Scotford, Cheng Jiang, Akshay Rao, Edward Harake, Asadur Chowdury, Wajd Al-Holou, Lin Wang, Aditya Pandey, Pedro Lowenstein, Maria Castro, Lisa Koerner, Thomas Roetzer-Pejrimovsky, Georg Widhalm, Sandra Camelo-Piragua, Misha Movahed-Ezazi, Daniel Orringer, Honglak Lee, Christian Freudiger, Mitchel Berger, Shawn Hervey-Jumper, and Todd Hollon

NATURE BIOMEDICAL ENGINEERING | 2024

Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy

Mustafa Nasir-Moin, Lisa Irina Wadiura, Vlad Sacalean, Devin Juros, Misha Movahed-Ezazi, Emily K. Lock, Andrew Smith, Matthew Lee, Hannah Weiss, Michael Müther, Daniel Alber, Sujay Ratna, Camila Fang, Eric Suero-Molina, Sönke Hellwig, Walter Stummer, Karl Rössler, Johannes A. Hainfellner, Georg Widhalm, Barbara Kiesel, David Reichert, Mario Mischkulnig, Rajan Jain, Jakob Straehle, Nicolas Neidert, Oliver Schnell, Jürgen Beck, Jay Trautman, Steve Pastore, Donato Pacione, Dimitris Placantonakis, Eric Karl Oermann, John G. Golfinos, Todd C. Hollon, Matija Snuderl, Christian W. Freudiger, Dieter Henrik Heiland, and Daniel A. Orringer

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ARXIV | 2024

A self-supervised framework for learning whole slide representations

Xinhai Hou *, Cheng Jiang*, Akhil Kondepudi, Yiwei Lyu, Asadur Zaman Chowdury, Honglak Lee, and Todd C. Hollon

CVPR WORKSHOP | 2024

Super-resolution of biomedical volumes with 2D supervision

Cheng Jiang, Alexander Gedeon, Yiwei Lyu, Eric Landgraf, Yufeng Zhang, Xinhai Hou, Akhil Kondepudi, Asadur Chowdury, Honglak Lee, and Todd C. Hollon

ARXIV | 2024

Step-Calibrated Diffusion for Biomedical Optical Image Restoration

Yiwei Lyu, Sung Jik Cha, Cheng Jiang, Asadur Chowdury, Xinhai Hou, Edward Harake, Akhil Kondepudi, Christian Freudiger, Honglak Lee, and Todd C. Hollon

JOURNAL OF NEUROSURGERY SPINE | 2024

Development and Validation of an Artificial Intelligence Model to Accurately Predict Spinopelvic Parameters

Edward S. Harake, Joseph R. Linzey, Cheng Jiang, Rushikesh S. Joshi, Mark M. Zaki, Jaes C. Jones, Siri S. Khalsa, John H. Lee, Zachary Wilseck, Jacob R. Joseph, Todd C. Hollon, and Paul Park

The Lancet Oncology | 2023

Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in- human trial

Yoshie Umemura, Daniel Orringer, Larry Junck, Maria L Varela, Molly E J West, Syed M Faisal, Andrea Comba, Jason Heth, Oren Sagher, Denise Leung, Aaron Mammoser, Shawn Hervey-Jumper, Daniel Zamler, Viveka N Yadav, Patrick Dunn, Wajd Al-Holou, Todd Hollon, Michelle M Kim, Daniel R Wahl, Sandra Camelo-Piragua, Andrew P Lieberman, Sriram Venneti, Paul McKeever, Theodore Lawrence, Ryo Kurokawa, Karen Sagher, David Altshuler, Lili Zhao, Karin Muraszko, Maria G Castro, and Pedro R Lowenstein

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CVPR | 2023

Hierarchical Discriminative Learning Improves Visual Representations of Biomedical Microscopy

Cheng Jiang*, Xinhai Hou*, Akhil Kondepudi, Asadur Chowdury, Christian W. Freudiger, Daniel A. Orringer, Honglak Lee, and Todd C. Hollon

NATURE MEDICINE | 2023

AI-based molecular classification of diffuse gliomas using rapid, label-free optical imaging

Todd Hollon, Cheng Jiang, Asadur Chowdury, Mustafa Nasir-Moin, Akhil Kondepudi, Alexander Aabedi, Arjun Adapa, Wajd Al-Holou, Jason Heth, Oren Sagher, Pedro Lowenstein, Maria Castro, Lisa Irina Wadiura, Georg Widhalm, Volker Neuschmelting, David Reinecke, Niklas von Spreckelsen, Mitchel Berger, Shawn Hervey-Jumper, John Golfinos, Matija Snuderl, Sandra Camelo-Piragua, Christian Freudiger, Honglak Lee, and Daniel Orringer

NEOPLASIA | 2023

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Wajd N. Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel GW Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel R Wahl, Todd Hollon, Oren Sagher, Jason A Heth, Karin M. Muraszko, Theodore S. Lawrence, Ana C de Carvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla

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NEURIPS DATASETS & BENCHMARKS | 2022

OpenSRH: optimizing brain tumor surgery using intraoperative stimulated Raman histology

Cheng Jiang*, Asadur Chowdury*, Xinhai Hou*, Akhil Kondepudi, Christian W. Freudiger, Kyle Conway, Sandra Camelo-Piragua, Daniel A. Orringer, Honglak Lee, and Todd C. Hollon

PITUITARY | 2022

Generating novel pituitary datasets from open-source imaging data and deep volumentric segmentation

Rachel Gologorsky, Edward Harake, Grace von Oiste, Mustafa Nasir-Moin, William Couldwell, Eric Oermann, and Todd Hollon

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NEUROSURGERY | 2022

Methods and Impact for Using Federated Learning to Collaborate on Clinical Research

Alexander T M Cheung, Mustafa Nasir-Moin, Young Joon Fred Kwon, Jiahui Guan, Chris Liu, Lavender Jiang, Christian Raimondo, Silky Chotai, Lola Chambless, Hasan S Ahmad, Daksh Chauhan, Jang W Yoon, Todd Hollon, Vivek Buch, Douglas Kondziolka, Dinah Chen, Lama A Al-Aswad, Yindalon Aphinyanaphongs, and Eric Karl Oermann

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CUREUS | 2022

Perigeniculate giant cell tumor of temporal bone

Eric E. Babajanian, Todd C. Hollon, Tori A. Seasor, William Couldwell, and Richard K. Gurgel

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WORLD NEUROSURGERY | 2022

Laminectomy at T4 and T5 for Resection of Symptomatic Cavernous Malformation

Vance L.Fredrickson Todd C.Hollon Robert C.Rennert Marcus D.Mazur Andrew T.Dailey, and William T.Couldwell

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NATURE COMMUNICATIONS | 2022

Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression

Andrea Comba, Syed M. Faisal, Patrick J. Dunn, Anna E. Argento, Todd C. Hollon, Wajd N. Al-Holou, Maria Luisa Varela, Daniel B. Zamler, Gunnar L. Quass, Pierre F. Apostolides, Clifford Abel II, Christine E. Brown, Phillip E. Kish, Alon Kahana, Celina G. Kleer, Sebastien Motsch, Maria G. Castro and Pedro R. Lowenstein

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NEUROSURGERY | 2022

Rapid automated analysis of skull base tumor specimens using intraoperative optical imaging and artificial intelligence

Cheng Jiang, Abhishek Bhattacharya, Joseph Linzey, Rushikesh Joshi, Sung Jik Cha, Sudharsan Srinivasan, Daniel Alber, Akhil Kondepudi, Esteban Urias, Balaji Pandian, Wajd Al-Holou, Steve Sullivan, B. Gregory Thompson, Jason Heth, Chris Freudiger, Siri Khalsa, Donato Pacione, John G. Golfinos, Sandra Camelo-Piragua, Daniel A. Orringer, Honglak Lee, and Todd Hollon

OPERATIVE NEUROSURGERY | 2022

Cranio-Orbital Approach for Single-Stage En Bloc Resection of Optic Nerve Glioma: Technical Note

Vance L Fredrickson, Guilherme J Agnoletto, Todd C Hollon, Bornali Kundu, Vance R Mortimer, William T Couldwell

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WORLD NEUROSURGERY | 2022

Microsurgical Excision of Ruptured Lenticulostriate Artery Aneurysm

Vance L Fredrickson, Serge Makarenko, Todd C Hollon, Robert C Rennert, Ramesh Grandhi, William T Couldwell

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FRONTIERS IN ONCOLOGY | 2021

Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications

Andrea Comba, Syed M Faisal, Maria Luisa Varela, Todd Hollon, Wajd N Al-Holou, Yoshie Umemura, Felipe J Nunez, Sebastien Motsch, Maria G Castro, and Pedro R Lowenstein

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NEURO-ONCOLOGY | 2021

Rapid, label-free detection of diffuse glioma recurrence using intraoperative stimulated Raman histology and deep neural networks

Todd C Hollon, Balaji Pandian, Esteban Urias, Akshay V Save, Arjun R Adapa, Sudharsan Srinivasan, Neil K Jairath, Zia Farooq, Tamara Marie, Wajd N Al-Holou, Karen Eddy, Jason A Heth, Siri Sahib S Khalsa, Kyle Conway, Oren Sagher, Jeffrey N Bruce, Peter Canoll, Christian W Freudiger, Sandra Camelo-Piragua, Honglak Lee, Daniel A Orringer

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WORLD NEUROSURGERY | 2021

Ventricular Volume Change as a Predictor of Shunt-Dependent Hydrocephalus in Aneurysmal Subarachnoid Hemorrhage

Haley K Talbot-Stetsko, Kristen D Raue, Bryan L Aaron, Arjun R Adapa, David B Altshuler, Sudharsan Srinivasan, Aditya S Pandey, Cormac O Maher, Todd C Hollon, Siri Sahib S Khalsa

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ACTA NEUROCHIRURGICA | 2021

Idiopathic chronic temporal lobe herniation with associated epilepsy

Austin Gamblin, Vance L Fredrickson, Todd C Hollon, Karen L Salzman, William T Couldwell

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JOURNAL OF NEUROSURGERY | 2020

Volumetric quantification of aneurysmal subarachnoid hemorrhage independently predicts hydrocephalus and seizures

Badih J. Daou, Siri Sahib S. Khalsa, Sharath Kumar Anand, Craig A. Williamson, Noah S. Cutler, Bryan L. Aaron, Sudharsan Srinivasan, Venkatakrishna Rajajee, Kyle Sheehan, and Aditya S. Pandey

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JOURNAL OF NEUROSURGERY PEDIATRICS | 2020

Normal cerebral ventricular volume growth in childhood

Noah S Cutler , Sudharsan Srinivasan , Bryan L Aaron, Sharath Kumar Anand , Michael S Kang, David B Altshuler, Thomas C Schermerhorn, Todd C Hollon , Cormac O Maher , and Siri Sahib S Khalsa

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CNS ONCOLOGY | 2020

Automated histologic diagnosis of CNS tumors with machine learning

Siri Sahib S Khalsa, Todd C Hollon, Arjun Adapa, Esteban Urias, Sudharsan Srinivasan, Neil Jairath, Julianne Szczepanski, Peter Ouillette, Sandra Camelo-Piragua, Daniel A Orringer

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NATURE MEDICINE | 2020

Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks

Todd C Hollon, Balaji Pandian, Arjun R Adapa, Esteban Urias, Akshay V Save, Siri Sahib S Khalsa, Daniel G Eichberg, Randy S D'Amico, Zia U Farooq, Spencer Lewis, Petros D Petridis, Tamara Marie, Ashish H Shah, Hugh J L Garton, Cormac O Maher, Jason A Heth, Erin L McKean, Stephen E Sullivan, Shawn L Hervey-Jumper, Parag G Patil, B Gregory Thompson, Oren Sagher, Guy M McKhann 2nd, Ricardo J Komotar, Michael E Ivan, Matija Snuderl, Marc L Otten, Timothy D Johnson, Michael B Sisti, Jeffrey N Bruce, Karin M Muraszko, Jay Trautman, Christian W Freudiger, Peter Canoll, Honglak Lee, Sandra Camelo-Piragua, Daniel A Orringer

BMC MEDICINE | 2019

Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann-Pick diseases

Mark L Schultz, Maria V Fawaz, Ruth D Azaria, Todd C Hollon, Elaine A Liu, Thaddeus J Kunkel, Troy A Halseth, Kelsey L Krus, Ran Ming, Emily E Morin, Hayley S McLoughlin, David D Bushart, Henry L Paulson, Vikram G Shakkottai, Daniel A Orringer, Anna S Schwendeman, Andrew P Lieberman

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JOURNAL OF NEUROSURGERY | 2018

A machine learning approach to predict early outcomes after pituitary adenoma surgery

Todd C Hollon, Adish Parikh, Balaji Pandian, Jamaal Tarpeh, Daniel A Orringer, Ariel L Barkan, Erin L McKean, Stephen E Sullivan

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CRITICAL CARE MEDICINE | 2018

Clinical Factors Associated With ICU-Specific Care Following Supratentoral Brain Tumor Resection and Validation of a Risk Prediction Score

Lynze R Franko, Todd Hollon, Joseph Linzey, Christopher Roark, Venkatakrishna Rajajee, Kyle Sheehan, Magnus Teig, Shawn Hervey-Jumper, Jason Heth, Daniel Orringer, Craig A Williamson

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JOURNAL OF NEUROSURGERY | 2017

Korsakoff syndrome from retrochiasmatic suprasellar lesions: rapid reversal after relief of cerebral compression in 4 cases

Luis E Savastano, Todd C Hollon, Ariel L Barkan, Stephen E Sullivan

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JOURNAL OF NEUROLOGICAL SURGERY | 2018

Surgical Treatment of Olfactory Neuroblastoma: Major Complication Rates, Progression Free and Overall Survival

Aileen Wertz, Todd Hollon, Lawrence J Marentette, Stephen E Sullivan, Jonathan B McHugh, Erin L McKean

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JOURNAL OF CLINICAL NEUROSCIENCE | 2018

Primary diffuse leptomeningeal melanomatosis: Description and recommendations

Yamaan S Saadeh, Todd C Hollon, Amanda Fisher-Hubbard, Luis E Savastano, Paul E McKeever, Daniel A Orringer

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WORLD NEUROSURGERY | 2018

Microvascular Brainstem Ischemia After Vestibular Schwannoma Surgery: A Clinical and Microanatomic Study

Todd C Hollon, Luis E Savastano, Davis P Argersinger, Douglas J Quint, B Gregory Thompson

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CANCER RESEARCH | 2018

Rapid Intraoperative Diagnosis of Pediatric Brain Tumors Using Stimulated Raman Histology

Todd C Hollon, Spencer Lewis, Balaji Pandian, Yashar S Niknafs, Mia R Garrard, Hugh Garton, Cormac O Maher, Kathryn McFadden, Matija Snuderl, Andrew P Lieberman, Karin Muraszko, Sandra Camelo-Piragua, Daniel A Orringer

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JOURNAL OF NEUROSURGERY PEDIATRICS | 2017

Comparison of posterior fossa volumes and clinical outcomes after decompression of Chiari malformation Type I

Siri Sahib S Khalsa, Alan Siu, Tiffani A DeFreitas, Justin M Cappuzzo, John S Myseros, Suresh N Magge, Chima O Oluigbo, and Robert F Keating

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NATURE BIOMEDICAL ENGINEERING | 2017

Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy

Daniel A Orringer, Balaji Pandian, Yashar S Niknafs, Todd C Hollon, Julianne Boyle, Spencer Lewis, Mia Garrard, Shawn L Hervey-Jumper, Hugh J L Garton, Cormac O Maher, Jason A Heth, Oren Sagher, D Andrew Wilkinson, Matija Snuderl, Sriram Venneti, Shakti H Ramkissoon, Kathryn A McFadden, Amanda Fisher-Hubbard, Andrew P Lieberman, Timothy D Johnson, X Sunney Xie, Jay K Trautman, Christian W Freudiger, Sandra Camelo-Piragua

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JOURNAL OF NEUROSURGERY PEDIATRICS | 2017

Morphometric and volumetric comparison of 102 children with symptomatic and asymptomatic Chiari malformation Type I

Siri Sahib S Khalsa, Ndi Geh, Bryn A Martin, Philip A Allen, Jennifer Strahle, Francis Loth, Desale Habtzghi, Aintzane Urbizu Serrano, Daniel McQuaide, Hugh J L Garton, Karin M Muraszko, Cormac O Maher

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JOURNAL OF NEUROSURGERY | 2016

Supratentorial hemispheric ependymomas: an analysis of 109 adults for survival and prognostic factors

Todd Hollon, Vincent Nguyen, Brandon W Smith, Spencer Lewis, Larry Junck, Daniel A Orringer

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PM&R | 2016

Delayed Sciatic Nerve Injury Resulting From Myositis Ossificans Traumatica

Zhe Guan, Thomas J Wilson, Jon A Jacobson, Todd C Hollon, Lynda J-S Yang

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JOURNAL OF NEUROSURGERY | 2016

Improving the accuracy of brain tumor surgery via Raman-based technology

Todd Hollon, Spencer Lewis, Christian W Freudiger, X Sunney Xie, Daniel A Orringer

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WORLD NEUROSURGERY | 2016

Surgical Management of Skull Base Rosai-Dorfman Disease

Todd Hollon, Sandra I Camelo-Piragua, Erin L McKean, Stephen E Sullivan, Hugh J L Garton

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NEUROSURGERY | 2016

Outcome of Transsphenoidal Surgery for Cushing Disease: A Single-Center Experience Over 32 Years

William F Chandler, Ariel L Barkan, Todd Hollon, Alla Sakharova, Jayson Sack, Barunashish Brahma, David E Schteingart

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SEMINARS IN RADIATION ONCOLOGY | 2015

Advances in the Surgical Management of Low-Grade Glioma

Todd Hollon, Shawn L Hervey-Jumper, Oren Sagher, Daniel A Orringer

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CHILD'S NERVOUS SYSTEM | 2015

Skull fracture mimicking eosinophilic granuloma

Todd Hollon, Paul E McKeever, Hugh J L Garton, Cormac O Maher

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CANCER RESEARCH | 2013

Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations

Richard L Price, Jieun Song, Katherine Bingmer, Tae Hyong Kim, Ji-Yeun Yi, Michal O Nowicki, Xiaokui Mo, Todd Hollon, Eric Murnan, Christopher Alvarez-Breckenridge, Soledad Fernandez, Balveen Kaur, Andreana Rivera, Michael Oglesbee, Charles Cook, E Antonio Chiocca, Chang-Hyuk Kwon

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